Simple, rapid and novel potentiometric method is developed for the determination of nifedipine in tablets. The proposed method is based on the reduction of the nitro group to amino group of the molecule with zinc and hydrochloric acid. The reduced molecule was diazotised with sodium nitrite at 5-10 oC. The reactions were carried out in aqueous medium without use of organic solvents. This method was validated statistically by low values of statistical parameters viz, standard deviation, relative standard deviation and standard error of mean. This method is novel, economic and eco-friendly as the method does not involve the use of any organic solvent. The proposed method is recommended for quality control, routine analysis and developed for academic purpose.
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